2,3-Dichloroquinoxaline
- Product Name
- 2,3-Dichloroquinoxaline
- CAS No.
- 2213-63-0
- Chemical Name
- 2,3-Dichloroquinoxaline
- Synonyms
- cp42103-4;NSC 33437;oroquinoxaL;AKOS BBS-00006726;TIMTEC-BB SBB003555;SALOR-INT L497169-1EA;3-Dichloroquinoxaline;2,3-DICHLOROQUINOXALINE;2,3-dichloro-quinoxalin;2,3-Dichlcroquinoxaline
- CBNumber
- CB5414800
- Molecular Formula
- C8H4Cl2N2
- Formula Weight
- 199.04
- MOL File
- 2213-63-0.mol
2,3-Dichloroquinoxaline Property
- Melting point:
- 152-154 °C (lit.)
- Boiling point:
- 325.69°C (rough estimate)
- Density
- 1.4994 (rough estimate)
- refractive index
- 1.6400 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- Water Solubility
- Insoluble in water
- solubility
- soluble in Chloroform
- form
- Needles
- pka
- -4.78±0.48(Predicted)
- color
- Off-white to light brown
- BRN
- 126076
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- InChIKey
- SPSSDDOTEZKOOV-UHFFFAOYSA-N
- CAS DataBase Reference
- 2213-63-0(CAS DataBase Reference)
- EPA Substance Registry System
- 2,3-Dichloroquinoxaline (2213-63-0)
Safety
- Hazard Codes
- T
- Risk Statements
- 25-36/37/38
- Safety Statements
- 26-36/37/39-45-37/39-28A
- RIDADR
- 2811
- WGK Germany
- 3
- RTECS
- VD1720000
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29339900
- Toxicity
- mouse,LD50,intravenous,5600ug/kg (5.6mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03256,
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 144525
- Product name
- 2,3-Dichloroquinoxaline
- Purity
- 96%
- Packaging
- 10g
- Price
- $59.9
- Updated
- 2024/03/01
- Product number
- 144525
- Product name
- 2,3-Dichloroquinoxaline
- Purity
- 96%
- Packaging
- 50g
- Price
- $274
- Updated
- 2023/06/20
- Product number
- D2622
- Product name
- 2,3-Dichloroquinoxaline
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $48
- Updated
- 2024/03/01
- Product number
- D2622
- Product name
- 2,3-Dichloroquinoxaline
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $145
- Updated
- 2024/03/01
- Product number
- A11734
- Product name
- 2,3-Dichloroquinoxaline, 98%
- Packaging
- 25g
- Price
- $142.65
- Updated
- 2024/03/01
2,3-Dichloroquinoxaline Chemical Properties,Usage,Production
Description
2,3-Dichloroquinoxaline (DCQX) can be used as a substrate for nucleophilic aromatic substitution (SNAr) reactions and is a versatile building block for the synthesis of many quinoxaline derivatives. 2,3-Dichloroquinoxaline reacts with 6-aminothiouracil in ethanol/TEA to form 6-amino-2-(3-chloroquinoxalin-2-ylthio)pyrimidin-4(3H)-one. It reacts with cholest-5-en-3-one semicarbazone/thiosemicarbazone to form steriodal cholest-5-en-3-oxazolo and thiazoloquinoxaline.
Chemical Properties
solid
Uses
2,3-Dichloroquinoxaline is a dichlorinated quinoxaline derivative with antimicrobial activity. 2,3-Dichloroquinoxaline is used in the preparation of quinoxaline derivatives of cancer chemopreventive a ctivity.
Uses
2,3-Dichloroquinoxaline was used in the synthesis of mono and 2,3-disubstituted quinoxalines. It was used in solid phase synthesis of HPLC chiral stationary phase containing the N,N′-dialkyl-2,3-diaminoquinoxaline group as a linking structure.
Preparation
To a stirred solution of quinoxaline-2,3(1H,4H)-dione (5.00 g, 1.0 equiv.), POCl3 was added (20 ml) and refluxed at 100 °C for 3h. After completion of the reaction, as indicated by TLC, the reaction mass was distilled under vaccum and quenched with ice cold water. Off white semi solid was formed and is filtered through buchner funnel under vaccum to yield the 2,3-dichloroquinoxaline in excellent yield.
Appearance: off white solid; Yield: 92% (5.64g); ESI-MS: (m/z) calcd. for C8H4Cl2N2: 197.98, found: 199.10 [M+H]+.
General Description
Gray solid. Insoluble in water.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
A halogenated amine. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Fire Hazard
2,3-Dichloroquinoxaline is probably combustible.
Purification Methods
Recrystallise it from *C6H6 and dry it in a vacuum [Cheeseman J Chem Soc 1804 1955, Beilstein 23/7 V 144].
2,3-Dichloroquinoxaline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,3-Dichloroquinoxaline manufacturers
- Product
- 2,3-Dichloroquinoxaline 2213-63-0
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99.8%
- Supply Ability
- 10000ton
- Release date
- 2024-04-25
- Product
- 2,3-Dichloroquinoxaline 2213-63-0
- Price
- US $0.00/KG
- Min. Order
- 100g
- Purity
- 98%+
- Supply Ability
- 100kg
- Release date
- 2020-09-10
- Product
- 2,3-Dichloroquinoxaline 2213-63-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99.00%
- Supply Ability
- 100tons
- Release date
- 2023-09-26